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A study about the effects of chemotherapy on glucocorticoid and sex hormone

A study about the effects of chemotherapy on glucocorticoid and sex hormone

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085676
Enrollment
Unknown
Registered
2024-06-14
Start date
2024-06-22
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastroenteric tumor

Interventions

control group:None

Sponsors

First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 ) male 18-50 years old, premenopausal women ( 18-50 years old, including 50 years old ), postmenopausal women ( 50 years old or older, menopause for more than 1 year ) ; ( 2 ) Primary gastric cancer or colorectal cancer, surgical treatment, postoperative adjuvant chemotherapy ; ( 3 ) The postoperative chemotherapy regimen was mFOLFOX6 or FLOT.

Exclusion criteria

Exclusion criteria: ( 1 ) Patients who need to receive glucocorticoid therapy due to indications other than tumor chemotherapy ; ( 2 ) critically ill patients with severe complications ; ( 3 ) have serious underlying diseases ( such as coronary heart disease, hypertension, diabetes, severe renal insufficiency, etc. ) ; ( 4 ) Patients with other adrenal diseases and pituitary diseases ( such as congenital adrenal hyperplasia, Cushing 's syndrome, aldosteronism, pheochromocytoma, pituitary tumor, hypopituitarism, etc. ) ; ( 5 ) patients with ovarian tumors, germ cell tumors ( such as dysgerminoma, seminoma, etc. ) ; ( 6 ) due to chemotherapy requires the use of glucocorticoid or gonadal hormone, or analogues or antagonists, etc. ; ( 7 ) Sex hormone drugs ( such as progesterone, estrogen and contraceptives ) were used within 1 month.

Design outcomes

Primary

MeasureTime frame
cortisol;adrenocorticotropic hormone;estradiol;testosterone;progesterone;luteinizing hormone;follicle stimulating hormone;

Secondary

MeasureTime frame
prolactin; kalium;natrium;blood glucose;blood pressure;heart rate;

Countries

China

Contacts

Public ContactBingyin Shi

First Affiliated Hospital of Xi'an Jiaotong University

shibingy@126.com+86 85323970

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026