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Effects of hippocampal avoidance on anxiety condition for patients with nasopharyngeal carcinoma undergoing intensity-modulated radiotherapy: A Single-Center, Single-Arm, Prospective Clinical Trial

Effects of hippocampal avoidance on anxiety condition for patients with nasopharyngeal carcinoma undergoing intensity-modulated radiotherapy: A Single-Center, Single-Ar

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085648
Enrollment
Unknown
Registered
2024-06-14
Start date
2023-08-07
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasopharyngeal carcinoma

Interventions

Experimental group:None

Sponsors

The First Affiliated Hospital of Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) age between 18 and 75 years at the time of diagnosis; 2)histologically confirmed NPC 3)planning to receive radical intensity modulated radiotherapy ± chemotherapy; 4)HADS-A scores=10 before radiotherapy; 5) Karnofsky Performance Status score = 70; 6) voluntary completion of the questionnaire.

Exclusion criteria

Exclusion criteria: 1)T4 staging (AJCC 8th edition) and tumor involvement of the cavernous sinus or cranial nerve; 2)presence of a second primary malignant tumor; 3)cerebrovascular disease, history of brain surgery, or other central nervous system diseases; 4)history of mental or psychological illness or long-term use of sedatives or anxiolytics, or recent use of such drugs; 5)the expected survival period is less than 1 year.

Design outcomes

Primary

MeasureTime frame
The incidence of anxiety;

Secondary

MeasureTime frame
The correlation between dosimetric parameters in various subregions of the hippocampus and the incidence of anxiety;Changes in the incidence of cognitive impairment;Target coverage;Conformity index;Homogeneity index;1-year local control rate;

Countries

China

Contacts

Public ContactJinsheng Hong

The First Affiliated Hospital of Fujian Medical University

13799375732@163.com+86 137 9937 5732

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026