Central nervous system infection
Conditions
Interventions
Gold Standard:Take clinical diagnosis as the gold standard. Cerebrospinal fluid culture
Index test:Biomarkers screened by interactive transcriptology to identify CNS infection
Sponsors
Beijing Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age: 29 days to 18 years old; 2. All enrolled children met the modified version of World Health Organization (WHO) classification criteria for bacterial meningitis surveillance cases or the criteria for suspected encephalitis cases
Exclusion criteria
Exclusion criteria: 1. cases of autoimmune encephalitis; 2. tumors with central nervous system involvement; 3. cases with bloody cerebrospinal fluid; 4. the volume of cerebrospinal fluid was less than 1ml;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathogen detection rate;Sensitivity;specificity;Accuracy ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total length of hospitalization;Duration of pathogen diagnosis;Antibiotic usage;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactGuo Lingyun
Beijing Children's Hospital
Outcome results
None listed