Perioperative Pain
Conditions
Interventions
placebo group:An appropriate amount of normal saline was injected into the patients nose 30min before anesthesia induction
Dexmedetomidine group:Before 30 minutes anesthesia induction,2ug/kg of dexmedetomidine was injected into the patients nose.
Dexmedetomidine combined with esketamine group:Before 30 minutes anesthesia induction,1 ug/kg of dexmedetomidine and 0.6 mg/kg of esketamine was injected into the patients nose.
Sponsors
Xuzhou Children's Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: (1) Age 2 ~ 7 years old; (2) American Society of Anesthesiology (ASA) physical status (I&II); (3) patients undergoing tonsillectomy and/or adenoidectomy;
Exclusion criteria
Exclusion criteria: (1) The child or his/her parents refused to participate in the study; (2) Participated in other clinical trials within 4 weeks before enrollment; (3) History of long-term use of narcotics or taking esketamine; (4) Allergy to dexmedetomidine or esketamine; (5) weight greater than the 95th percentile of that age and sex; (6) Known cardiopulmonary disease (such as uncorrected congenital heart disease, primary or secondary pulmonary hypertension, tumor or structural lung disease); (7) Mental retardation or vision and hearing problems that cause inability to communicate; (8) Children with intraocular pressure and intracranial hypertension; (9) Children with electrocardiogram showing conduction block and sick sinus syndrome; (10) Family history of mental illness, etc.;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction ComplianceChecklist;PAED score;Ramsay Sedation score;recovery time;Time of Removing the endotracheal tube;Anxiety scores;Score of sedation during awakening;Time of stay in the PACU;Remifentanil consumption;Analgesic consumption;Intraoperative blood pressure;Intraoperative heart rate;Pre-induction sedation score;Incidence of adverse events;Incidence of sleep disturbances;Pain score at three months postoperatively; | — |
Countries
China
Contacts
Public ContactZhang Yueying, Li Li
Xuzhou Children's Hospital
Outcome results
None listed