chronic thromboembolic pulmonary disease
Conditions
Interventions
BPA+Anticoagulation group:none
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: ?Age =18 years old and =85 years old; ?Patients with pulmonary embolism who have received standardized anticoagulation for at least 3 months; ?Patients with dyspnea; ?CT pulmonary angiography (CTPA) or ventilation/perfusion (V/Q) scan suggests chronic thrombosis and lesions are operable for BPA; ?Right heart catheterization(RHC) at rest: mPAP=20mmHg; ?Patients can endure exercise RHC and are diagnosed ePH. Diagnostic criteria for ePH: mPAP at rest = 20 mmHg, ?mPAP/?CO between exercise and rest > 3 mmHg/L/min (Refer to the recommendations of 2022 ESC/ERS PH guideline).
Exclusion criteria
Exclusion criteria: ? Pregnancy or lactation; ? Combined with other serious diseases: ALT or AST is 3 times higher than the upper limit of normal values, or creatinine clearance <50ml/min, hemoglobin <10g/dl, etc.; ? Simultaneously participating in another study or within one month after completing another study. ? Patients with uncorrected intracardiac and aortic shunts; ? Patients with lower limb movement disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary vascular resistance; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute walking distance;WHO functional class;BNP or NT-proBNP;TAPSE(Echocardiography);PASP (Echocardiography);TAPSE/PASP (Echocardiography);SF-36 Quality of Life Score; | — |
Countries
China
Contacts
Public ContactJun Wan
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed