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The preventive effect of different doses of norepinephrine combined with compound sodium chloride on hypotension during cesarean section

The preventive effect of different doses of norepinephrine combined with compound sodium chloride on hypotension during cesarean section

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085623
Enrollment
Unknown
Registered
2024-06-14
Start date
2024-06-14
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension after spinal anesthesia

Interventions

Control group:None
N1 group: epinephrine 0.01ug/kg/min+0.4ml · kg-1 · h-1 intravenous infusion+bupivacaine 1.8ml spinal anesthesia
N2 group:Norepinephrine 0.025ug/kg/min+0.4ml · kg-1 · h-1 intravenous infusion+bupivacaine 1.8ml spinal anesthesia
N3 group:Norepinephrine 0.05ug/kg/min+0.4ml · kg-1 · h-1 intravenous infusion+bupivacaine 1.8ml spinal anesthesia
N4 group:Norepinephrine 0.1ug/kg/min+0.4ml · kg-1 · h-1 intravenous infusion+bupivacaine 1.8ml spinal anesthesia

Sponsors

Guyuan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 35 Years

Inclusion criteria

Inclusion criteria: ? Individuals aged 21-35 years old; ? Individuals classified by the American Society of Anesthesiologists (ASA) as Grade I-II; ? Body mass index (BMI)<35, ? Primiparous women who have a single full-term pregnancy and plan to undergo cesarean section at a later date

Exclusion criteria

Exclusion criteria: ? Patients with pregnancy induced hypertension and pregnancy induced diabetes; ? Individuals with severe cardiac and pulmonary dysfunction; ? Patients with contraindications related to combined lumbar epidural anesthesia; ? Dropout midway

Design outcomes

Primary

MeasureTime frame
heart rate;blood pressure;Neonatal score;

Secondary

MeasureTime frame
Carotid artery corrected blood flow time (ultrasound evaluation);

Countries

China

Contacts

Public Contactzhouxiaogang

Guyuan People's Hospital()

524472158@qq.com+86 187 9511 1736

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026