Knee Osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. those who meet the diagnostic criteria for osteoarthritis of the knee in Western medicine and traditional Chinese medicine; 2. aged between 40 and 80 years old, gender is not limited; 3. patients who have already received other non-surgical treatments after a 7-day washout period; 4. informed consent and volunteer to be tested. The process of obtaining informed consent should be in accordance with GCP.
Exclusion criteria
Exclusion criteria: 1. those with osteoarthritis of the knee accompanied by acute synovitis; 2. those with knee osteoarthritis tuberculosis, tumor, rheumatoid arthritis, rheumatoid arthritis 3. those with concurrent diseases affecting the joints, such as psoriasis, syphilitic neuropathy, brown-yellow disease, metabolic bone disease, acute trauma, etc; 4. Those who have undergone knee replacement; 5. receiving systemic or intra-articular hormone therapy within 60 days, and having had intra-articular injections or arthroscopy of the knee within 3 months; 6. patients who are participating in clinical trials of other drugs; 7. require pain medication (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs, compounded over-the-counter medications with pain-relieving ingredients, herbal medications that may contain pain-relieving active ingredients, topical pain relievers) due to other chronic or recurrent pain in addition to KOA; 8. other pathologies or conditions that, in the judgment of the investigator, have the effect of reducing the likelihood of enrollment or complicating enrollment, such as frequent changes in the work environment that could lead to loss of visits; 9. have serious heart, liver, lung, kidney, blood or other serious illnesses affecting their survival 10. having mental illness 11. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammatory factors (IL-1ß, IL-6, TNF-a, NGF);Visual Analogue Scale;Western Ontario and McMaster Universities Arthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital anxiety and depression scale; | — |
Countries
China
Contacts
Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Provincial Hospital of Chinese Medicine)