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Study of predisposing genes and clinical prognostic assessment of polygenic risk in patients with premature myocardial infarction

Study of predisposing genes and clinical prognostic assessment of polygenic risk in patients with premature myocardial infarction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085600
Enrollment
Unknown
Registered
2024-06-13
Start date
2024-06-17
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute myocardial infarction

Interventions

Case series:None

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:1. Using the Chinese arteriosclerosis risk assessment model CHINA-PAR, those with a 10-year and low lifetime risk of arteriosclerosis cardiovascular disease (ie, a 10-year risk assessment of less than 5.0% and a lifetime risk assessment of less than 32.8%) were screened. 2. Patients and their parents volunteered to participate in the study and signed the informed consent. 3. Han nationality, no consanguineous marriage.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. There are clear secondary causes, such as familial hypercholesterolemia, thrombophilia, systemic vasculitis, connective tissue disease, coronary artery dilatation, dissection, etc. . If necessary, the relevant tests were supplemented and judged by 2 senior cardiovascular specialists after analyzing the patient's medical records and the results of auxiliary examinations. 2. The father or mother of the patient was not able to participate.

Design outcomes

Primary

MeasureTime frame
Clinical data;Clinical outcomes of patients with myocardial infarction after discharge;Cumulative Incidence of Major Clinical Events;Cardiovascular Death and All-Cause Death;Nonfatal myocardial infarction;Non-fatal stroke;Revised Revascularization;Readmission for unstable angina;

Secondary

MeasureTime frame
Whole Genome Sequencing;

Countries

China

Contacts

Public ContactFan Zhongjie

Peking Union Medical College Hospital

fanzhongjie@pumch.cn+86 131 4642 1559

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026