Obesity
Conditions
Interventions
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for obese patients: 1) Age 18-60 years (2) Body mass index (BMI) =30kg/m2 (3) Proposed laparoscopic sleeve gastrectomy 4) Patients agreed and signed an informed consent form Inclusion criteria for normal weight study participants: 1) Age 18-60 years old (2) BMI between 18.5 and 24.9 kg/m2. 3) Agreed and signed an informed consent form
Exclusion criteria
Exclusion criteria: Exclusion criteria for obese patients: 1) Patients with severe cardiovascular disease or unstable angina pectoris 2) History of psychiatric disorders, especially those affecting appetite and weight, such as depression, bipolar disorder 3) Use of medications that may significantly affect body weight or metabolism, such as antidepressants, steroids, or antipsychotics. 4) Presence of endocrine disorders known to directly affect body weight and metabolism, e.g., hyper- or hyperthyroidism, Cushing's disease 5) History of neurological disease or significant brain injury 6) Participants who refuse to participate in a clinical trial, sign an informed consent form, or participate in another study at the same time. Exclusion criteria for normal weight study participants: 1) Presence of any chronic disease that may affect body weight or neurological function, such as cardiovascular disease, diabetes, mental illness, blood system diseases, etc. 2) Have abnormal liver function 3) Use of medication that affects body weight, metabolism, or neurological function. 4) Have a history of major neurological disease or brain injury. 5) Recent significant weight changes or extreme dietary behaviours 6) Participants who refuse to participate in the clinical trial, refuse to sign the informed consent form, or participate in other studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heparan Sulfate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ferritin;C-reactive protein,CRP;Interleukin;NAR;NLR;PNR;PLR;PWR;Cranial diffusion tensor imaging;Central inflammatory markers; | — |
Countries
China
Contacts
Public ContactYu Qiong
Huashan Hospital, Fudan University
Outcome results
None listed