Knee osteoarthritis
Conditions
Interventions
Test group 1:Cartilage repair techniques were performed
Test group 2:Oral tonifying kidney dehumidifying prescription combined with cartilage repair technique
Control group:Oral Western medicine (diclofenac sodium sustained-release tablets + glucosamine sulfate capsules)
Sponsors
Wangjing Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
38 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ? Meet the diagnostic standards of Western medicine and Chinese medicine; (Western diagnostic criteria: 1. According to the American College of Rheumatology (ACR) diagnostic criteria for knee osteoarthritis: ?. Knee pain most days of the month; 2. There is a sound when the joint is moving; 3. Morning stiffness 38 years old; ?. Bone swelling of knee joint with bouncing; 6. bone swelling of knee joint without rattle; At least ? ~ ? or ?, ?, ?, ? or ? and ? can be diagnosed. 2.Kellgren-LawranceX line classification (divided into 5 levels) : Level 0: normal; Grade I: Suspected joint space stenosis and possible labial hyperplasia; Grade II: Definite osteophytes and possible joint space stenosis; Grade III: moderately multiple osteophytes, certain joint space stenosis, sclerosis, and possible bone end deformation; Grade IV: Large osteophytes, marked joint space narrowing, severe sclerosis, and definite end deformation. 3. MRI grading of articular cartilage degeneration (RECHT grading) Grade 0: Normal articular cartilage; Grade I: The hierarchical structure of cartilage disappeared, the focal low signal area appeared in the cartilage, and the cartilage surface was smooth; Grade II: The surface profile of the cartilage is light to moderate irregular, and the depth of the cartilage defect is less than 50% of the full thickness. Grade III: Moderate to severe irregularities in the surface profile of the cartilage, with a depth of cartilage defect of more than 50% of the full thickness but no complete detachment. Grade IV: full-layer cartilage defect, exfoliation, subchondral bone exposure, with or without subchondral bone signal changes. TCM diagnostic criteria: TCM diagnostic and syndrome criteria refer to the 2018 edition of the Chinese Association of Integrated Traditional and Western Medicine Orthopedics Professional Committee "Knee Osteoarthritis of Traditional Chinese and Western Medicine Integrated Diagnosis and Treatment Guide" in the diagnosis and treatment of liver and kidney deficiency type KOA diagnostic criteria: dull joint pain, waist and knee weakness, more severe in case of labor, red tongue, less mossiness, pulse heavy and weak. Only those who meet the above criteria can be diagnosed.) (2) meet the requirements of the clinical indications studied; ? Age >38 years old; ? In line with Kellgren-Lawrance X-ray classification level 0, I, II; (5) MRI showed focal RECHT grade III and IV cartilage degeneration. ? Sign the informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria: ? Those who do not meet the above diagnostic criteria and inclusion criteria. ? Observers who have received other relevant treatments that may affect the effect indicators of this study. ? Patients with life-threatening primary diseases such as cardiovascular and cerebrovascular diseases, liver and kidney diseases and mental disorders. ? Excluded diseases for study: a. Rheumatic diseases: rheumatoid arthritis, ankylosing spondylitis, etc.; b. Infectious arthritis: joint tuberculosis, suppurative arthritis, etc.; c. Reactive arthritis: allergic arthritis, thrombocytopenic arthritis, etc.; d. Metabolic arthropathy: Kaschin-beck disease, gout, etc.; e. Intraarticular tumors; f. Other specific joint diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum index;WOMAC Osteoarthritis Index score;Lequesne Index score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Roberts MRI evaluation criteria;MOCART MRI cartilage repair score;TCM clinical symptom score; | — |
Countries
China
Contacts
Public ContactLin Jing
Wangjing Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed