delirium
Conditions
Interventions
hemoperfusion group:Using HA380 hemoperfusion device during cardiopulmonary bypass
control group:Using conventional cardiopulmonary bypass without HA380 hemoperfusion.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: ?Patients older than 65 years old.?Elective cardiopulmonary bypass for combined valve replacement/plasty, ascending aortic aneurysm surgery, etc., with an expected CPB time of more than 2 hours.?Volunteer to participate in this study and sign informed consent form.
Exclusion criteria
Exclusion criteria: ?Patients with cognitive disorders, Alzheimer's disease, anxiety and other mental disorders.?Patients with liver diseases, renal insufficiency, or cerebrovascular diseases.?Using psychotropic drugs or other drugs that interfere the evaluation of delirium and cognitive function.?Patients with serious problem in hearing and understanding, or who are unable to cooperate and provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;IL-6;IL-10;S100ß protein;NSE;Procalcitonin (PCT);C-reactive protein (CPR);Alanine transaminase (ALT);Aspartate transaminase (AST);Creatinine (Cr);Blood gas parameters;Length of hospital stay;Length of ICU hospital stay;Duration of mechanical ventilation;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLihua Lei
Fujian Provincial Hospital
Outcome results
None listed