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Effect of SGLT2 inhibitors on coronary microcirculation function in patients with coronary heart disease complicated with Type 2 Diabetes Mellitus

Effect of SGLT2 inhibitors on coronary microcirculation function in patients with coronary heart disease complicated with Type 2 Diabetes Mellitus

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085512
Enrollment
Unknown
Registered
2024-06-11
Start date
2024-06-21
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary atherosclerotic heart disease complicated with Type 2 Diabetes Mellitus

Interventions

Not receiving treatment with SGLT2 inhibitors group:None
Receiving treatment with SGLT2 inhibitors group:None

Sponsors

Tianjin Fourth Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 87 Years

Inclusion criteria

Inclusion criteria: (1) Patients with coronary heart disease: meet the WHO diagnostic criteria for coronary heart disease. (2) Type 2 diabetes patients: diabetes patients meet the diagnostic criteria for diabetes in the Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes (2020);(3)Age = 18 years old, male or female, Complete clinical data.(4)The interval of coronary angiography was more than half a year, and the patients were not treated with PCI. (5)The coronary angiography image quality is clear and the image meets the QFR measurement requirements.

Exclusion criteria

Exclusion criteria: (1)Patients who cannot tolerate coronary angiography.(2)Autoimmune diseases, tumors, severe renal insufficiency (eGFR < 30ml/min/1.73m^2), severe cardiac insufficiency, severe infections, or other diseases that significantly affect the microcirculation status.(3)acute myocardial infarction.(4)Previous CABG history.(5)Poor image quality, unable to identify the outline of the blood vessels.(6)The target vessel is severely twisted and overlapped.(7) Clinical or angiographic conditions limiting QFR calculation (left main disease, CTO disease, progressive ventricular arrhythmia, or persistently significant tachycardia).

Design outcomes

Primary

MeasureTime frame
Angio—IMR, AMR;

Countries

CHINA

Contacts

Public ContactLiu Yong

Tianjin Fourth Central Hospital

13820788667@163.com+86 138 2078 8667

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026