total knee arthroplasty
Conditions
Interventions
experimental group:tourniquet use during surgery
control group:without tourniquet use during surgery
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Aged =60 years; 2. ASA grade I-III; 3. Planned to undergo unilateral total knee arthroplasty under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Communication barriers; 2.Patients with preoperative cognitive impairment; 3. History of mental illness; 4. Severe arrhythmia, heart failure, acute coronary syndrome, severe liver and renal dysfunction; 5.Severe anemia or coagulation dysfunction; 6. Rheumatic disorders; 7.Contraindications of tourniquet use. 8.Allergic to any of the medications used; 9.History of other surgeries within six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration and severity of delirium;Incidence of deep vein thrombosis;Incidence of pulmonary complications;Incidence of acute kidney injury;Incidence of surgical site infection;Incidence of ICU admission;Length of hospital stay;Maximum pain score within 24 hours postoperatively;Analgesic consumption within 24 hours postoperatively;Incidence of rescue analgesia within 24 hours postoperatively;Blood loss volume;Inflammatory markers;Biomarkers of oxidative stress;Brain injury markers;Hypoxia response indicators;Nutritional indicators;Time to first ambulation postoperatively; | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed