sepsis induced myocardial dysfunction
Conditions
Interventions
sham transcutaneous auricular vagus nerve stimulation (sham taVNS):Wear an transcutaneous auricular vagus nerve stimulator, but do not give electrical stimulation
transcutaneous auricular vagus nerve stimulation (taVNS):Transcutaneous Auricular vagus nerve stimulation
Sponsors
Qilu Hospital of Shandong University (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign informed consent; 2. Adult patients (=18 years old); 3. No gender restriction; 4. Patients diagnosed with sepsis, echocardiography within 24 hours of sepsis diagnosis indicated LVEF < 50%.
Exclusion criteria
Exclusion criteria: 1. Previous history of myocardial ischemia, atrial fibrillation or valvular heart disease; 2. Patients suspected with acute coronary syndrome; 3. Patients with implanted devices (such as cardiac defibrillators or pacemakers); 4. Ear skin disease or infection; 5. Pregnant or breastfeeding; 6. Patients who are unable to stay still during treatment (such as epilepsy or Parkinson's disease); 7. Palliative care or clinician judgment that the patient is expected to die within 72 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Echocardiography LVESD, LVEF, LVEDD, LVEDV, and LVESV;Serum levels of NT-proBNP, cTn I, CKMB and MYO, and serum levels of inflammatory factors;SOFA score and APACHE II score;The dosage of vasoactive drugs and the amount of crystal/colloidal fluids used for resuscitation;28 day mortality;ICU stay;heart rate variability; | — |
Countries
China
Contacts
Public ContactWu Zhiyang
Qilu Hospital of Shandong University (Qingdao)
Outcome results
None listed