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Clinical observation of Yuebi Jia-Banxia decoction in the treatment of AECOPD (phlegm-heat syndrome) and preliminary study on the mechanism of AGE-RAGE

Clinical observation of Yuebi Jia-Banxia decoction in the treatment of AECOPD (phlegm-heat syndrome) and preliminary study on the mechanism of AGE-RAGE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085497
Enrollment
Unknown
Registered
2024-06-10
Start date
2024-06-10
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AECOPD

Interventions

Control group :? Continuous low flow oxygen (1-3L/min) was given
? Budesonide suspension for inhalation 1mg+ compound ipratropium bromide solution for inhalation 2.5ml nebulized to relieve spasmodic asthma, bid
? Initial empirical treatment according to the common pathogens of clinical experience, blood (sputum) culture and drug sensitivity test should be collected, and antibiotics should be adjusted accordi
treatment group:The more oral menservants and Yue maideng and Banxia decoction

Sponsors

Panyu Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 85 Years

Inclusion criteria

Inclusion criteria: ? In accordance with the diagnostic criteria of western medicine AECOPD, the severity of lung function was classified as ?-?, and in accordance with the diagnostic criteria of TCM phlegm-heat obstructing the lung syndrome (including newly diagnosed or previously diagnosed COPD patients); ? age between the age of 40 to 85 (including boundary value), no sex; ? voluntarily participated in the study and signed the informed consent.

Exclusion criteria

Exclusion criteria: ? Pregnant and lactating women; ? Acute respiratory failure requiring invasive mechanical ventilation; ? refusing to sign the informed consent form with poor compliance; ? those who were allergic to any component of the conventional treatment drugs or Yuemei Jiabanxia decoction during the trial; ? combined with bronchial asthma, pulmonary tuberculosis and other serious underlying diseases; ? and patients who did not meet the above inclusion criteria.

Design outcomes

Primary

MeasureTime frame
Effective rate;Interleukin-6;

Secondary

MeasureTime frame
TCM symptom score;White cell count;C - reactive protein;Tumor necrosis factor;PaO2;PaCO2;advanced glycosylation end products,AGEs;Solublereceptor for advanced glycationend,sRAGE;

Countries

China

Contacts

Public ContactSheng Luo

Panyu Hospital of Traditional Chinese Medicine

tcm2007@163.com+86 135 6018 4296

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026