Bipolar disorder is a chronic condition that affects the functioning of the brain and, as a serious mental illness, is characterized by significant fluctuations in mood, energy levels, and behavior, and these fluctuations are usually manifested in two main phases: a manic (or hypomanic) phase and a depressive phase. These mood swings are not ordinary mood ups and downs, but rather extreme emotiona
Conditions
Interventions
77.5Hz-tACS group:77.5Hz-tACS treatment
sham 77.5Hz-tACS group:sham 77.5Hz-tACS treatment
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Be between 18 and 60 years of age; 2. Diagnosed with bipolar disorder type I or II in accordance with the diagnostic criteria of the U.S. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) or ICD-10; 3. Have experienced at least one manic or hypomanic episode and one depressive episode in the past 12 months; 4. Not experiencing severe psychotic symptoms (e.g., hallucinations or delusions) for at least 6 months prior to enrollment; 5.The patient's physical examination, medical history, vital signs, blood, urine and stool routines, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are normal; 6.After fully understanding the safety of transcranial alternating current stimulation (tACS), the patient is willing to actively cooperate with the treatment, and the patient and his/her family members sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Age 60 years; 2. History of serious physical illness; 3. Patients with metallic or electronic instruments placed in the body, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 4. Those at risk for seizures, with a history of craniosynostosis, head trauma, alcoholism, abnormal electroencephalograms, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 5. Those with psychotic symptoms requiring a combination of should antipsychotic medications; 6. Receiving other physical therapy after enrollment; 7. Those who are pregnant, breastfeeding, or planning to become pregnant during the trial; 8. Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromyographic changes;EEG changes;Near infrared functional imaging;nuclear magnetic;Behavioral tasks; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed