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Effect of dexmedetomidine combined with dexamethasone on postoperative nausea and vomiting and plasma 5-HT, prostaglandins, and beta-endorphin in patients with breast cancer (a randomized controlled, double-blind prospective study)

Effect of dexmedetomidine combined with dexamethasone on postoperative nausea and vomiting and plasma 5-HT, prostaglandins, and beta-endorphin in patients with breast cancer (a randomized controlled, double-blind prospective study)

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085484
Enrollment
Unknown
Registered
2024-06-07
Start date
2024-06-15
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Control group (saline group):Same volume of saline
Dexmedetomidine group:Dexmedetomidine
Dexamethasone group:Dexamethasone
Dexmedetomidine combined with dexamethasone group:Dexmedetomidine combined with dexamethasone

Sponsors

Affiliated Hospital of Sichuan Bei Medical College
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients with radical mastectomy for breast cancer; 2.ASA classification I~II; 3.Age 18~65 years old; 4.Weight: 45-60kg.

Exclusion criteria

Exclusion criteria: Antiemetic and corticosteroid treatment 24h before surgery; glutamyl transferase, creatinine and urea nitrogen higher than twice the normal value; allergy to dexmedetomidine, allergy to non-steroidal analgesics; sinus bradycardia and/or atrioventricular block; functional adrenal tumors, including Cushing's syndrome, primary aldosteronism, and pheochromocytoma; pregnant women, obese patients [Body Mass Index (BMI)?34kg/m^2]; diabetes; gastroduodenal ulcers; uncooperative patients. 34kg/m2]; diabetes mellitus; gastroduodenal ulcer; patients who cannot cooperate.

Design outcomes

Primary

MeasureTime frame
postoperative nausea and vomiting;—

Secondary

MeasureTime frame
plasma 5-HT;prostaglandins;beta-endorphin;blood glucose;Antiemetic use;—

Countries

China

Contacts

Public ContactFangjun Wang

Affiliated Hospital of Sichuan Bei Medical College

lin1992104@163.com+86 134 5825 3172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026