Depression
Conditions
Interventions
A-cTBS group:Accelerated cTBS intervention
Sham a-cTBS group:Sham a-cTBS intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Be 18 to 65 years of age; 2) Diagnosis of depression in accordance with the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) or ICD-10; 3) A total HAMD-17 score of >=17; 4) Right-handedness; 5) The patient's physical examination, medical history, vital signs, blood, urine and stool routine, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are normal; 6) After fully understanding the safety of transcranial magnetic stimulation (TMS), they are willing to actively cooperate with the treatment and sign informed consent by themselves and their families.
Exclusion criteria
Exclusion criteria: 1) Those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 2) Patients with metallic or electronic instruments placed in the body, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 3) Those at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 4) Those with psychotic symptoms requiring a combination of should antipsychotic medications; 5) Receiving other physical therapy after enrollment; 6) Those who are pregnant, breastfeeding, or planning to become pregnant during the trial; 7) Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromyographic changes;EEG changes;Near infrared functional imaging;Imaging indicators;Behavioral; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed