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Effect of peripherally applied dexamethasone on rebound pain after nerve block in patients with upper extremity fractures, a randomized controlled study

Effect of peripherally applied dexamethasone on rebound pain after nerve block in patients with upper extremity fractures, a randomized controlled study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085479
Enrollment
Unknown
Registered
2024-06-07
Start date
2023-12-29
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rebound pain after nerve block in patients with upper extremity fractures

Interventions

control group:normal saline
Dexamethasone group 1:Intravenous bolus of 5 mg of dexamethasone is given immediately after completion of the nerve block
Dexamethasone group 2:Intravenous bolus of 10 mg of dexamethasone is given immediately after completion of the nerve block

Sponsors

The Second Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing upper limb fracture surgery (elbow and below) under supraclavicular brachial plexus block; 2. Age range from 18 to 80 years old; 3. ASA is classified as Level I or II; 4. All patients or family members sign informed consent forms; 5. All signed informed consent forms for postoperative pain relief within 48 hours after surgery, and all used sufentanil for postoperative pain relief;

Exclusion criteria

Exclusion criteria: 1. Allergy or contraindications to the drugs used in the test; 2. Coagulation disorders; 3. Patients with preoperative nerve injury; 4. Diabetics; 5. Patients taking sedative, analgesic and psychotropic drugs for a long time; 6. Inability to cooperate with pain scoring; 7. Refusal to use self-controlled analgesia (PCA); 8. Failure of nerve block; 9. Infection or damage to the puncture site; 10. Failure to complete intraoperative data collection and postoperative follow-up.

Design outcomes

Primary

MeasureTime frame
Incidence of rebound pain at 24 hours after operation;

Secondary

MeasureTime frame
Time of onset, duration and intensity of rebound pain;Postoperative complications (nausea and vomiting, infections, etc.);Number of PCIA self-administrations and rescue analgesic consumption at 48 hours;Pain scores at scheduled time points;Duration of nerve block;

Countries

China

Contacts

Public ContactZhang Ru Meng

The Second Hospital of Shandong University

zrm19940321@163.com+86 176 6008 3850

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026