acne vulgaris
Conditions
Interventions
Research group :For external use, once a day, in the evening, take an appropriate amount of ointment. After dinner, apply a thin layer of benzoyl peroxide gel simulator to the affected area, wipe the
control group:For external use, once a day, in the evening, take an appropriate amount of ointment. After dinner, apply a thin layer of Longzhu ointment simulant to the affected area, wipe the affecte
Sponsors
Dongfang Hospital of Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 18 to 50 years old, regardless of gender; 2. According to the PILLSBURY international improved classification system, patients clinically diagnosed with acne vulgaris grades II-III have facial features that meet the following criteria: 20-50 inflammatory skin lesions (papules, pustules, and nodules), 25-100 non inflammatory skin lesions (open and closed acne), no more than 2 facial nodules, and an IGA score of moderate; 3. The subject agrees to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who are known to be allergic to any component in Longzhu Ointment (artificial musk, borax, calcined calamine, ammoniacal ammonia, borneol, artificial bezoar, pearl (made), amber, and the auxiliary materials are yellow vaseline, lanolin, liquid paraffin) and any component in peroxybenzoyl gel, or the allergic body is not suitable for participating in this study after evaluation by the researcher; 2. Patients with facial complications and other skin diseases that may significantly affect the efficacy evaluation, such as sunburn dermatitis, hormone dependent dermatitis, rosacea, psoriasis, seborrheic dermatitis, eczema, etc; 3. Patients who have used topical acne treatment drugs within the first 2 weeks of the study, or those who have taken antibiotics, retinoids, and other acne treatment drugs orally within 4 weeks; 4. Having excessive facial hair (such as beard, sideburns, etc.) may interfere with the diagnosis and evaluation of acne vulgaris; 5. Patients who received photodynamic therapy within the first three months of the study; 6. Pregnant or women preparing for pregnancy and lactation within six months; 7. Participants in other clinical trials within the first three months prior to the start of this study; 8. The researchers believe that due to other reasons, it is not suitable for participants to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| On the 8th and 15th day of medication, the percentage change in inflammatory skin lesion counts (erythema, pustules, and papules) compared to baseline values in each group after treatment;;Comparison of percentage changes in inflammatory skin lesion count before and after treatment between the study group and the control group on the 8th and 15th day of medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| On the 8th and 15th day of medication, the researcher determined that IGA treatment was successful, and the difference between the study group and the control group;On the 8th and 15th day of medication, there was a difference in the percentage change in non inflammatory skin lesion count (nILC) between the study group and the control group compared to baseline.; | — |
Countries
China
Contacts
Public Contactfengchuan zhang
Dongfang Hospital of Beijing University of Traditional Chinese Medicine
Outcome results
None listed