Knee Osteoarthritis in women
Conditions
Interventions
Cohort study group:No
Routine intervention group:Regular verbal and written guidance
APP intervention group:Using an APP for intervention guidance
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
Female
Age
45 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Female patients in the outpatient Department of Osteoarthrosis, Peking University Shenzhen Hospital. 2. Between 45 and 55 years old. 3. Body mass index between 20-35 kg/m2. 4. K-L grade of knee joint is less than grade 2. 5. WOMAC score is less than 10 points. 6. The knee resting or exercise VAS score was less than or equal to 3 points, and the pain was sporadic. 7. Multimodal prediction models predict the risk of knee osteoarthritis in postmenopausal women as high-risk patients. 8. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Women with history of knee surgery, history of knee infection, history of knee trauma. 2. Women with knee joint stiffness and ankylosis. 3. Patients with muscle strength grade 3 and below. 4. Women with a long history of contraceptive use. 5. Women with gynecological tumors. 6. Women with chronic metabolic diseases such as diabetes. 7. Women with language and intellectual disabilities who cannot complete the scale detection and examination required by the project. 8. Women with central or peripheral neuropathy affecting normal walking and functional exercise. 9. Women with previous digestive tract ulcers. 10. Women who, for various reasons, were unable to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of knee osteoarthritis;Knee joint ortho X-ray K-L grade 2 or above; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the joint space between the medial or lateral compartments of the knee joint from baseline on X-rays of the knee joint in an upright position;VAS score under resting and exercise conditions;WOMAC score;Measurement of quadriceps muscle strength;SF-36 score;Serum biomarkers; | — |
Countries
China
Contacts
Public ContactDeli Wang
Peking University Shenzhen Hospital
Outcome results
None listed