TKA patients
Conditions
Interventions
The oxycodone group:Postoperative analgesia PCIA(5 oxycodone +0.9%NS to 150ml), the first dose: 0ml/h
Maintenance volume 3ml/h
PCA: 2ml
Lock time: 30min
The nalbuphine group:Postoperative analgesia PCIA(5 nalbuphine +0.9%NS to 150ml), the first dose: 0ml/h
Sponsors
Panzhihua Central Hospital
Eligibility
Sex/Gender
All
Age
19 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 19-80; 2) body mass index (BMI) 18-35kg/?; 3) American Society of Anesthesiologists (ASA) grades I - III; 4) Patients with elective TKA; 5) Patients who are able to understand and willing to use VAS score to report pain.
Exclusion criteria
Exclusion criteria: 1) The patient refuses; 2) Allergic to drugs used during anesthesia; 3) Long-term use of opioids, sedatives, antidepressants, monoamine oxidase inhibitors and other drugs; 4) Systemic or puncture site infection; 5) Serious complications before operation (coagulation dysfunction, severe hypertension, heart failure, severe arrhythmia, severe lung disease, severe liver and kidney insufficiency, digestive ulcer, mental or nervous system disease, cognitive dysfunction); 6) Refuse postoperative analgesia; 7) Chronic pain in the past; 8) Obstructive sleep apnea syndrome; 9) Language communication barriers; 10) Follow-up failure or withdrawal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores at rest and exercise 2h, 4h, 6h, 12h, 24h, 48h after surgery;The number of postoperative analgesic pump compressions 2h, 4h, 6h, 12h, 24h, 48h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, blood pressure and pulse oxygen saturation of patients 2h, 4h, 6h, 12h, 24h and 48h after surgery;Postoperative remedial analgesic drugs and dosage;Postoperative sedation score 2h, 4h, 6h, 12h, 24h, 48hRamsay;Patient satisfaction score;First time out of bed activity;hospital stays;Postoperative complications (postoperative delirium, nausea and vomiting, hypoxemia, hypotension, bradycardia, respiratory depression, pruritus, etc.); | — |
Countries
China
Contacts
Public ContactBangjian Zhang
Panzhihua Central Hospital
Outcome results
None listed