sarcopenia
Conditions
Interventions
Nutrition Education + Probiotics and protein group: Nutrition Education + 40g protein pre day, and life enhancer probiotics including bacillus coagulans (5*10^8CFU/g) and clostridium butylicum (5*10^7
Nutrition Education + Probiotics placebo and protein group:Nutrition Education + 40g protein pre day and Probiotics placebo tablets twice a day.
Nutrition Education + Probiotics group : Nutrition Education + Life enhancer probiotics including bacillus coagulans (5*10^8CFU/g) and clostridium butylicum (5*10^7 CFU/g), twice a day.
Nutrition Education + Probiotics placebo group:Nutrition Education + Probiotics placebo tablets twice a day.
Sponsors
Shanghai fourth people's hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) =60 years old, gender is not limited; (2) According to the Asian Working Group for Sarcopenia (AWGS), patients should meet the diagnostic standards of sarcopenia; (3) Patients should have the ability to oral feeding and tolerate nutritional supplements; (4) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who can't tolerate nutritional supplements; (2) Patients who have diseases that seriously affect the digestion and absorption of nutritional supplements; (3) Patients who have severe kidney or liver failure, or malignancies that are receiving chemotherapy or with edema, have mental disorders before trail. (4) Patients have dysfunction of lower limb joint, which could affect walking independently; (5) Patients who have been implanted metal or electronic devices into the body that affect the examination; (6) Patients who are using medication interfering with the nutritional intervention; (7) Patients who are using drugs that may affect the trail ( such as hormones, anti-tumor drugs, sedation or other muscle relaxants); (8) Those who have taken antibiotics or probiotics within one month; (9) Other reasons that were not suitable for clinical trials; (10) Patients who disagree to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| indexes of skeletal muscle mass; | — |
Secondary
| Measure | Time frame |
|---|---|
| gut microbiota;nutritional indices;inflammatory index;quality of life assessment; | — |
Countries
China
Contacts
Public ContactWang Ying
Shanghai fourth people's hospital
Outcome results
None listed