Anti-wrinkle
Conditions
Interventions
Blank group:Do no processing
Oral group:Take only oral products Nutrilite Keyuan Xinhuo drinks.
External service group:Only use artistry sodium hyaluronic acid vitamin C multi-effect essence for external use.
Oral group + External service group:Take the oral product Nutrilite Keyuan Xinhuo Drink and use the external cosmetic Artistry Sodium Hyaluronate Vitamin C Multi-effect Essence.
Sponsors
Beijing EWISH Testing Technology Co., Ltd
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ? Age and sex requirements: 18-60 years old Chinese healthy female subjects; ? Indoor workers; ? Skin condition requirements: skin dry, dull, stained, dull, slack and other skin troubles; ? The mean F4 values of left and right corner skin were =6, or the mean R2 values were =0.65; ? Self-reported wrinkles or fine lines around the eyes, relaxed; At the same time, the eye wrinkles/fundus fine lines/upper eyelids ptosis/interbrow lines = grade 2 (refer to Skin Aging Atlas Volume 2, 2010); ?Have the habit of daily use of sunscreen products, and should not change the daily sunscreen and cleaning habits during the test; ? Volunteers to participate in this study, and comply with the requirements of the test for return visits, discomfort can respond in time; ?The test area has not been exposed to the sun for a long time in the past 8 weeks, no sunbathing; ? Can ensure that during the test period do not use the same type of bath or any other useful activities at the test site; ? Can ensure that the test site during the test to avoid the sun, heavy scrubbing or dermabrasion treatment; ? Be able to accept test takers who complete tests according to test requirements; ? Those who have no pregnancy or lactation plans throughout the study period and are able to commit to avoiding pregnancy during the study period; ?Subjects who are using hormone replacement therapy or hormonal fertility control should be able to ensure that their original use habits are maintained during the trial period, and subjects who are not using such hormones should ensure that they are not using such hormones during the trial period; ? Those who can promise not to do spa, swimming or bathing during the test period; ?Persons with no allergic disease, no history of allergy to cosmetics, skin care products and other topical preparations; ? Persons without heart, immune, blood vessel, liver, gallbladder, kidney and other systemic diseases; ?Persons who are able to guarantee abstinence from alcohol throughout the trial period; ?Those who can cooperate well with the test subjects and maintain the regularity of life during the study period; ? Can cooperate well with the use of products, understand and fill in project questionnaires and cooperate with staff.
Exclusion criteria
Exclusion criteria: ? Breast-feeding or pregnant women, or subjects who have planned to be pregnant and breast-feeding recently; ? Those with skin history of psoriasis, eczema, atopic dermatitis and severe acne; ? Subjects with sunburn or unavoidable sunlight exposure in the working environment; ?People who have the habit of taking slimming ? Use the essence containing more than 5% VC and VC derivatives; ? Those who went to the beauty salon for nursing in the past month; ? Have received cosmetic surgery on face or mandible, catgut embedding, fat filling, face-lifting needle, hyaluronic acid, water needle and other injection cosmetic services, laser beauty such as picosecond, photon rejuvenation, photoelectric energy beauty such as hot Maggie, and others that may affect the test results; ?Take hydroxy acids, whitening drugs and anti-aging drugs within one month; Used hydroquinone drugs within 2 months; Topical use of retinoids within 3 months and oral use of retinoids within one year; ?Pet-name ruby is known to be allergic to food, skin care products, cosmetics or topical drugs or sensitive person; ?Attending the need for systemic or local use of any drugs that affect skin surface parameters during the test; ?The test site has birthmarks, scratches, white spots, pigmented nevus, keloids and other skin features that affect the test; ?Subjects who have a history of acute or chronic skin diseases, or whose physical health may affect the test results; ?Those who have a history of smoking; ?People with asthma and hay fever; ?The clinical judge thinks that it is not suitable to participate in the researcher; ?Those who have participated in other clinical trials in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin firmness F4;Skin firmness R2;Image capture;Volume of marionette line;Depth of marionette line;Area of marionette line;Perimeter of lacrimal groove;Volume of Lacrimal groove ;Depth of tear groove;Regular grain area;Statue grain volume;Depth of grain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Water content ;TEWL; | — |
Countries
China
Contacts
Public ContactYao Pan
Beijing Technology and Business University
Outcome results
None listed