Major depressive disorder
Conditions
Interventions
Health group:None
Major Depressive disorder:Divenlafaxine sustained-release tablets
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
8 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for MDD patients: age range 8-65 years; Understand the research content and sign the informed consent; Meet the DSM-5 diagnostic criteria; Baseline score HAMD-17=18; Domicile fixed, able to complete 12 weeks of acute treatment follow-up, and agreed to cooperate with the investigator to complete treatment follow-up on time. Healthy subjects: age range 8-65 years old; Understand the research content and sign the informed consent; Does not meet the DSM-5 diagnostic criteria; Recruited by health examination center or advertisement.
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy and MDD patients: patients with serious physical diseases (such as metabolic diseases, kidney diseases, liver diseases, thyroid diseases, etc.) or organic brain diseases, can refer to the laboratory abnormal indicators more than 2 times the normal value or combined with the study doctor's opinion; A history of loss of consciousness for more than 5 minutes; A history of alcohol or substance abuse/dependence within the past 1 year; Electroconvulsive therapy in the past six months; Regular use of addictive drugs within the last month; The presence of other mental disorders (personality disorders and mental retardation) that significantly affect the subject's current mental state; Currently have serious impulse or self-injury, suicide attempt; Pregnant or lactating women, or those planning to become pregnant; The investigators concluded that there was a lack of compliance with the clinical study or that compliance did not meet follow-up requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effective rate;remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-17 total score reduction rate;metabolome;proteome;Gut microbiome; | — |
Countries
China
Contacts
Public ContactChunhua Zhou
The First Hospital of Hebei Medical University
Outcome results
None listed