gastrointestinal malignancy
Conditions
Sponsors
the First Affiliated Hospital of the People's Liberation Army Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign an informed consent form. 2. No gender limit, age 18 to 75 years old (including threshold). 3. Gastroesophageal junction/colorectal adenocarcinoma (PD-L1 CPS = 5, MSI-H/dMMR) confirmed by histopathology and meeting the ICI treatment criteria, and confirmed by multiple imaging examinations as locally advanced (T2-4aN0-3M0, corresponding to stages Ib to IIIC). 4. Plan to receive a systemic treatment regimen containing ICI (which must include anti PD-1/PD-L1 monoclonal antibodies). 5. The ECOG (Eastern Cooperative Oncology Group Performance Status score) physical condition score is 0 or 1. 6. According to the patient's existing CT examination, there are measurable target lesions in the RECIST version 1.1 efficacy evaluation criteria.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary primary cancer other than gastrointestinal tumors. 2. Have received any intervention treatment within the previous month. 3. Preexisting history of autoimmune diseases and immunosuppressive drug treatment. 4. Unable to cooperate with lying on the PET/CT scanning bed during the scanning period or intolerant to PET examination. 5. According to the evaluation of the researchers, the subjects may have other circumstances that may affect the study or are not suitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUVmax;SUVmean;dNLR;LDH;sensitivity;specificity;accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| NLR;(Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactFei Kang
the First Affiliated Hospital of the People's Liberation Army Air Force Military Medical University
Outcome results
None listed