Parkinson's disease
Conditions
Interventions
real treatment group:intermittent theta-burst stimulation
Sponsors
The Second Affiliated Hospital of Xi 'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. PD patients diagnosed according to the PD diagnostic criteria formulated by MDS in 2018 have improved H&Y stage 1-3; 2. Age 18-85 years old; 3. Diagnosed with mild cognitive impairment of Parkinson's disease according to the Level II criteria of the Movement Disorders Association Working Group; 4. Receive normal anti-Parkinson's medication; 5. No obvious impairment of vision or corrected vision or hearing; 6. Good compatibility, with certain compliance; 7. Able to understand and cooperate with clinical evaluation and treatment; 8. Undertake to abide by the research procedures and cooperate with the implementation of the whole process of research; 9. Voluntary participation, the informed consent signed by the patient himself or by his immediate family members.
Exclusion criteria
Exclusion criteria: 1. There are serious cognitive and emotional disorders and it is difficult to complete the experiment; 2. History of other organic diseases of the central nervous system, such as cerebrovascular diseases, encephalitis, tumors, and severe epilepsy; 3. There are other diseases that affect cognitive function, such as Parkinson's syndrome; 4. Combined history of other mental illness or family history of mental illness, such as schizophrenia, bipolar disorder, autism; 5. There are metal objects in the skull, such as cerebrovascular stents, cochlear implants and other metal implants; 6. There are cardiac pacemakers, heart stents, etc.; 7. People with severe visual and hearing impairment; 8. Is participating in another clinical trial; 9. Any condition which, in the opinion of the investigator, is likely to harm the subject or cause the subject to be unable to meet or perform the study requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional near-infared soectroscopy;The Montreal Cognitive Assessment,MoCA;Animal Verbal Fluency Test;Trail Making Test;Clock Drawing Test,CDT;P300;PDQ-39; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD;HAMA; | — |
Countries
China
Contacts
Public ContactZhang Qiaojun
Department of Rehabilitation Medicine, the Second Affiliated Hospital of Xi 'an Jiaotong University
Outcome results
None listed