Gynecological laparoscopic surgery
Conditions
Interventions
Opioid free group :Opioid free group anesthesia induction: Esketamine 0.5mg/kg, propofol 2.5mg/kg, rocuronium 0.6mg/kg
Opioid free group anesthesia maintenance:Esketamine and rocuronium will be pumped
opioid group:opioid group anesthesia induction: Sufentanil 0.3µg/kg, propofol 2.5mg/kg, rocuronium 0.6mg/kg
opioid group anesthesia maintenance: Sufentanil and rocuronium will be pumped continuously
Sponsors
Shandong University Qilu Hospital Dezhou Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing laparoscopic surgery due to gynecological benign diseases, such as ovarian cysts, uterine fibroids, endometriosis, etc.; 2) Age: 18~60 years old; 3) ASA ?~? grade; 4) BMI=32kg/m²; 5) It indicates that it can cooperate with the investigation and provide clear evaluation data of postoperative nausea and vomiting, such as incidence and severity.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of substance abuse or opioid dependence; 2) Pregnant or nursing patients; 3) Patients with a history of allergy to esketamine or other related drugs; 4) Intraoperative conversion to laparotomy or operation time > 2h; 5) Patients with serious cardiovascular diseases and hyperthyroidism; 6) Patients at risk for increased cranial or intraocular pressure; 7) Patients with poorly controlled or untreated hypertension (resting arterial pressure >180/100 mmHg); 8) Patients with preoperative consciousness disorder or unable to cooperate with the interviewer due to other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of postoperative nausea and vomiting;Hemodynamic index;Pain score; | — |
Countries
China
Contacts
Public ContactXiangshuang Yao
Shandong University Qilu Hospital Dezhou Hospital
Outcome results
None listed