Uterine Cervical Lesions
Conditions
Interventions
Additional follow-up group (DNA methylation was used to guide referral for colposcopy):None
Standard follow-up group (Referral for colposcopy according to the Chinese Cervical Cancer Screening Guideline):None
Sponsors
Heze Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1.Females aged 35-64 years with a history of sexual life. 2.The remaining cell samples for DNA methylation testing can be collected. 3.Sign the informed consent form, be willing and able to accept colposcopy, and have histological results that meet the diagnostic criteria. 4.No history of cervical cancer and precancerous lesions treatment.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Women with immunodeficiency; 3. Women with a history of other gynecological malignancies and tumors; 4. Women with incomplete personal information: sample collection unit, name, age, cytology test results, HPV test results, colposcopy pathology results, cytology history within 5 years, and history of colposcopy within 5 years. 5.Known history of history of high-grade cervical lesions and above (CIN2, CIN3, cervical cancer) and history of ablative, excisional therapy to the cervix. 6.Subjects enrolled withdraw from reasearch. 7.Unable to meet the minimum required sample size.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation;Diagnosis proportion of CIN2+; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic proportion of CIN3+; | — |
Countries
China
Contacts
Public ContactChaohui Yuan; Longfang Xu
Heze Maternal and Child Health Hospital
Outcome results
None listed