sleep disturbance
Conditions
Interventions
experimental group:Postoperative analgesic formula in the experimental group (S group): sufentanil 2ug/kg + esketamine 0.72mg/kg + tropisetron 6mg
control group:Postoperative analgesic formula in the control group (C group): sufentanil 2ug/kg + tropisetron 6mg
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65-80 years undergoing hip replacement or knee arthroplasty; 2. ASA Grade was II-III.
Exclusion criteria
Exclusion criteria: 1. History of dementia or cognitive impairment as assessed by the Mini-Mental State Rating Scale (MMSE); 2. Has a history of severe liver (Child-Pugh grade C) or renal (requiring renal replacement therapy) disease; 3. Patients with poorly controlled or untreated hypertension (SBP more than 180 mmHg and DBP more than 100 mmHg in the resting state); 4. BMI=28kg/?; 5. Patients with ischemic heart disease and congestive heart failure; 6. History of glaucoma or hyperthyroidism; 7. Known allergy to any of the study drugs; 8. Mental illness; 9. Increased intracranial pressure; 10. Opioid dependence; 11. Patient has substance abuse that affects perception and pain assessment; 12. Long-term and severe sleep disturbance before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbances; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbances;Cognitive function;The number of effective compressions of the postoperative analgesic pump;Anxiety score;Depression scores;(QoR-15) recovery quality scale score; | — |
Countries
China
Contacts
Public ContactMing Yan
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed