postpartum depression
Conditions
Interventions
study group:Injection of esketamine 0.15mg/kg(20ml)
study group:Injection of esketamine 0.2mg/kg(20ml)
study group:Injection of esketamine 0.3mg/kg(20ml)
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: ) age between 20 and 35; 2)ASAII grade, BMI18-30kg/m2; 3) Single-term pregnant women who are scheduled to undergo cesarean section under spinal anesthesia; 4) preoperative e Edinburgh score scale < 10; 5) Understand clearly and voluntarily participate in the study, and sign the informed consent form by himself.
Exclusion criteria
Exclusion criteria: 1) Have a history of mental illness or family history or are using other antidepressants; 2) communication and communication barriers; 3) Hyperthyroidism, hypertension, pregnancy-induced hypertension or eclampsia; 4) Contraindications to esketamine: such as allergy, increased intracranial pressure, increased intraocular pressure and increased intragastric pressure; 5) Have a history of abuse of psychotropic drugs and/or alcohol; 6) Patients with chronic pain and/or long-term oral painkillers; 7) Long-term oral glucocorticoid; 8) Complicated with serious heart, lung, liver and renal dysfunction; 9) Fetus with congenital diseases or malformations; 10) local anesthetic allergy;11) Contraindications for intraspinal anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postpartum depression six weeks after operation;1, 2, 3 days of postoperative exercise and resting pain VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edinburgh Postpartum Depression scale score at 1 week, 2 weeks, 4 weeks and 6 weeks after operation;Ramsay score of 5 minutes after drug injection, at the end of the operation, and 1 day after surgery;BPRS+ score of 5 minutes after drug injection, at the end of the operation, and 1 day after surgery; | — |
Countries
China
Contacts
Public ContactWei Ke
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed