Epidural labor analgesia
Conditions
Interventions
Experimental group:The first woman in the study received a 5mg dose of esketamine. According to the maternal analgesic response, if the NRS score is less than 3, it is valid, and the next woman has an
Sponsors
Longyan First Hospital of Fujian Province
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Primipara, single fetus, head position, age 18-40 years old, BMI =36 kg/m^2, 37-42 weeks of pregnancy,ASA? or ? grade, prenatal examination such as obstetrics and B-ultrasonography, no contraindications for vaginal delivery, cervical dilation 2-4 cm, and willing to perform labor analgesia. The NRS pain score (the average pain score for three consecutive uterine contractions prior to painless delivery) is =6.
Exclusion criteria
Exclusion criteria: Multiparous women, multiple pregnancies, body mass index > 36 kg/m^2, pathological obstetric diseases; Allergy to related drugs (ropivacaine, esketamine); For long-term analgesics, opioid analgesics were used before epidural analgesia during delivery, oxytocin was given from 15 minutes before analgesia to 45 minutes after epidural analgesia, and cervical rapid changes (cervical dilation =5 cm) occurred within 45 minutes before analgesia; Contraindications to epidural anesthesia; Mental symptoms; NRS score < 6 before analgesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum effective dose of esketamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal vital signs, NRS score, fetal heart rate, Rmsay score, Bromage score, sensory block level;Neonatal umbilical artery blood gas analysis, neonatal Apgar score;Adverse reactions: dizziness, nausea and vomiting, bradycardia, hypotension, fever; | — |
Countries
China
Contacts
Public ContactXiaoqing Lin
Longyan First Hospital of Fujian Province
Outcome results
None listed