Pneumoconiosis
Conditions
Interventions
Pneumoconiosis + Low-dose Vitamin D group (Vitamin D 600IU, 2400IU/week):Low-dose Vitamin D , Vitamin D 600IU, 2400IU/week
Pneumoconiosis + High-dose Vitamin D group (Vitamin D 5000IU, 20000IU/week):High-dose Vitamin D , Vitamin D 5000IU, 20000IU/week
Pneumoconiosis + Tetrandrine (60mg/day) + Low-dose Vitamin D group (Vitamin D 600IU, 2400IU/week):Tetrandrine (60mg/day) + Low-dose Vitamin D, Vitamin D 600IU, 2400IU/week
Pneumoconiosis + Tetrandrine (60mg/day) + High-dose Vitamin D group (Vitamin D 5000IU, 20000IU/week):Tetrandrine (60mg/day) + High-dose Vitamin D, Vitamin D 5000IU, 20000IU/week
Sponsors
The Fifth People's Hospital of Suzhou
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients meeting all of the following criteria will be included in this study: 1) Outpatients or inpatients at our department who meet the diagnostic criteria for pneumoconiosis according to GBZ 70-2015; 2) Patients able to sign informed consent.
Exclusion criteria
Exclusion criteria: Patients with any of the following conditions will be excluded from this study: 1) Having other clear diseases affecting vitamin D levels, such as cardiovascular diseases, tumors, type 1 diabetes, parathyroid-related diseases, and autoimmune diseases; 2) Abnormal liver or kidney function and congenital diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walk test;Pulmonary function (diffusing capacity for carbon monoxide, DLCO); | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Medical Research Council (mMRC) Dyspnea Scale;The Epworth Sleeping Scale (ESS);STOP-Bang Questionnaire;Generalized Anxiety Disorder 7-item (GAD-7);Patient Health Questionnaire-9 (PHQ-9);Short Form Health Survey (SF-36);Montreal Cognitive Assessment (MoCA); | — |
Countries
China
Contacts
Public ContactYanmei Cao
The Fifth People's Hospital of Suzhou
Outcome results
None listed