Biomarkers for neonatal acute respiratory distress syndrome: a prospective cohort study

Discriminative study of neonatal acute respiratory distress syndrome (ARDS) and neonatal respiratory distress syndrome (NRDS) based on transcriptomics and proteomics

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400085274

Enrollment

Unknown

Registered

2024-06-04

Start date

2021-10-31

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neonatal acute respiratory distress syndrome

Interventions

Neonatal acute respiratory distress syndrome(<34w):N/A

Neonatal acute respiratory distress syndrome(=34w):N/A

Neonatal respiratory distress syndrome:N/A

Control:N/A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Newborns manifested with respiratory distress within 24 hours after birth, including progressive dyspnea, groaning, three concave sign, and cyanosis; (2) newborns need non-invasive or invasive respiratory support within 24 hours after birth; (3) Imaging showed RDS manifestations, including air bronchogram, ground-glass lung lesions, white lung, etc.

Exclusion criteria

Exclusion criteria: (1) The presence of congenital malformations/developmental abnormalities affecting respiratory function, such as congenital heart disease, diaphragmatic hernia, pulmonary stenosis; (2) Genetic metabolic diseases; (3) Abnormal structure of upper respiratory tract; (4) Intubation required for surgical operations; (5) Grade III or IV intracranial hemorrhage; (6) Family members are unwilling to participate in.

Design outcomes

Primary

Measure	Time frame
proteome;transcriptome;target molecule screened by proteome or transcriptome;	—

Countries

China

Contacts

Public ContactShi Yuan

Children's Hospital of Chongqing Medical University

shiyuan@hospital.cqmu.edu.cn+86 135 0830 0283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026