Sleep quality decreases after total knee arthroplasty
Conditions
Interventions
Experimental group:The test drug was added to the analgesia pump
Control group:Placebo was added to the analgesia pump
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 89 Years
Inclusion criteria
Inclusion criteria: (1) age =65 years old and <90 years old; (2) American Society of Anesthesiologists (ASA) grade I-III; (3) elective total knee arthroplasty under general anesthesia; (4) The operation was completed before 19:00; (5) Agree to participate in this study, agree to use intravenous analgesia pump, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) emergency surgery; (2) patients with high risk of obstructive sleep apnea (STOP-Bang questionnaire score of 3 or above) or diagnosed patients; (3) severe cardiac dysfunction (preoperative LVEF<30% or NYHA class IV); (4) severe liver dysfunction (Child-Pugh grade C); (5) severe renal dysfunction (dialysis before operation); (6) expected to be transferred to intensive care unit after surgery; (7) allergy to any component of ketamine/esketamine/dexmedetomidine; (8) had received ketamine/esketamine/dexmedetomidine treatment; (9) sleep disorders requiring medical intervention (e.g., hypnotics) within the past month; (10) patients with sick sinus syndrome, severe sinus bradycardia (heart rate <50 beats/min) and atrioventricular block above degree II before surgery without pacemaker implantation; (11) Unable to communicate and cooperate with the study due to severe dementia or language disorder before surgery. (12) preoperative schizophrenia, epilepsy, Parkinson's disease and myasthenia gravis;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality on the night of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| RCSQ score on the first and second postoperative nights;The use of intravenous analgesia pump, other analgesic drugs and NRS pain score were followed up 0.5 and RASS;PONV in 24 and 48 hours after surgery;Postoperative Cognitive function;Score of sleep; | — |
Countries
China
Contacts
Public ContactXiaoyan Wang
Weifang People's Hospital
Outcome results
None listed