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Clinical study of hydration prevents SGLT2i-associated post-contrast acute kidney injury among T2DM patients undergoing coronary angiography

Clinical study of hydration prevents SGLT2i-associated post-contrast acute kidney injury among T2DM patients undergoing coronary angiography

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085252
Enrollment
Unknown
Registered
2024-06-04
Start date
2024-11-16
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-contrast acute kidney injury

Interventions

Hydration group:0.9% saline 500 ml was given intravenously at a rate of 1 ml/kg/h 3-12 hours before surgery and 12-24 hours after surgery.
Non-hydration group:Non-hydration

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Clearly diagnosed "type 2 diabetes" and taking SGLT2i, regardless of medical history, age >=18 years; 2. eGFR >=60ml/(min-1.73 m2); 3. Proposed coronary angiography; 4. Voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Acute myocardial infarction with emergency coronary angiography; 2. Patients with severe heart failure (NYHA Class III-IV); 3. Patients with severe renal insufficiency (eGFR <60ml/(min.1.73m2)), or after renal transplantation, or maintenance hemodialysis or peritoneal dialysis; 4. Contrast allergy or repeated use of contrast within a short period of time (48-72 hours); 5. Rheumatic diseases; 6. Malignant tumors.

Design outcomes

Primary

MeasureTime frame
serum creatinine;

Secondary

MeasureTime frame
urine NGAL;KIM-1;

Countries

China

Contacts

Public Contactzang jia bin

Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

zangjb@mail3.sysu.edu.cn+86 189 3017 1102

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026