familial hypercholesterolemia
Conditions
Interventions
non-familial hypercholesterolemia patient group :None
familial hypercholesterolemia patient group :None
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The research subjects of this study were all from the population undergoing self hospital physical examination. In this population, the results of blood lipid testing were first screened to determine the hyperlipidemia patients among the healthy population undergoing physical examination; Among the screened patients with hyperlipidemia, individuals who meet the following inclusion and exclusion criteria will be included in the study cohort as FH group and non FH group, respectively; 2. FH group inclusion criteria: Those who meet two of the following three criteria: (1) Serum LDL-C = 4.90mmol/L in patients who have not received lipid-lowering drug treatment; (2) Having skin/tendon xanthoma or<45 years old but with fatty corneal arch; (3) FH or early-onset ASCVD among first-degree relatives, especially CAD patients; 3. Inclusion criteria for non FH group: Patients who are clearly diagnosed with hyperlipidemia but do not meet the FH diagnostic criteria.
Exclusion criteria
Exclusion criteria: 1. Patients who may experience secondary elevation of LDL-C levels due to complications, such as hypothyroidism, nephrotic syndrome, and biliary obstruction. 2. Patients who are unable to provide LDL-C levels or have not undergone LDL-C testing. 3. People with mental or neurological dysfunction who are unable to express themselves.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular and cerebrovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause mortality;myocardial infarct;heart failure; | — |
Countries
China
Contacts
Public ContactDilare·Adi
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed