Stroke
Conditions
Interventions
iTBS+startle group:Transcranial magnetic stimulation + Acoustic Startle Priming Motor Training
iTBS+non-startle group:Transcranial magnetic stimulation+ Normal Priming Training
sham iTBS+startle group:sham iTBS + Acoustic Startle Priming Motor Training
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1)Age between 18 and 70 years, with both males and females eligible. (2)Onset of the first stroke within the past 3 months, with clear clinical symptoms and radiological diagnosis. (3)Severe upper limb motor impairment, with a Fugl-Meyer Assessment-Upper Extremity (FMA-UE) score between 0 and 35. (4)Stable vital signs for at least 48 hours. (5)Cognitive capacity to follow instructions, with a Mini-Mental State Examination (MMSE) score of >= 22. (6)Tolerance to sudden auditory startling stimuli of 114 decibels. (7)Willingness to provide informed consent.
Exclusion criteria
Exclusion criteria: (1)A history of strokes. (2)Severe upper/lower limb spasticity, with a Modified Ashworth Scale (MAS) grade of 3 or higher, or other conditions affecting upper and lower limb function, such as joint muscle contractures, severe frozen shoulder, fractures, arthritis, local skin ulcers, pressure sores, recent surgical incisions, etc; (3)Severe cognitive impairment, inability to effectively communicate with medical personnel; (4)Other conditions deemed unsuitable for participation by the researcher, such as severe hypertension, coronary heart disease, claustrophobia, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugel-Myer motor Assessment for upper extremity, FMA-UE;modified Ashworth scale, MAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| MEP;rest-state function MRI;diffusion tensor image;Quality of life;Retention rate;Adherence;Tolerability;Safety; | — |
Countries
China
Contacts
Public ContactJing Zhang
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed