The Tuina intervention effect of post-stroke depression behavior symptoms and HPA axis-inflammatory factors

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400085211

Enrollment

Unknown

Registered

2024-06-03

Start date

2024-06-03

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post stroke depression

Interventions

control group:Conventional rehabilitation training will be used in this trial. Brunnstrom's neurofacilitation techniques was mainly used for treatment intervention. Techniques include: positioning and

Tuina group:The Tuina group will receive the rehabilitation treatment consistent with the control group. Building upon this, the optimized version of the "Tongdu Sushen" massage therapy protocol will

the treatment will be completed by the same Tuina therapist throughout.

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: ?Meet the diagnostic criteria for post-stroke depression in the "Chinese Expert Consensus on Clinical Practice of Post-Stroke Depression." ?Aged between 40 and 80 years. ?No consciousness disorders, aphasia, liver or kidney dysfunction, stable vital signs. ?Signed informed consent. ?Brain injury in the non-dominant hemisphere.

Exclusion criteria

Exclusion criteria: ?Those who do not meet the above diagnostic and inclusion criteria. ?Individuals with contraindications to blood tests . ? Patients with suicide risk. ? Patients in the acute phase of stroke (within two weeks) or progressive phase with unstable vital signs.?Severe post-stroke depression (HAMD > 24 points). ?Patients with severe cognitive impairment (MMSE = 9 points). ?Recurrent depression, treatment-resistant depression, or prolonged and difficult-to-treat depressive symptoms. ? Other emotional disorders after stroke, such as anxiety, fear, etc.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Rating Scale(HAMD);IL-2;IL-4;IL-5;IL-6;IL-8;IL-10;IL-12P70;IL-17;TNF-a;Interferon ?;Interferon a;IL-1ß;Adrenocorticotropic Hormone(ACTH);cortisol;	—

Secondary

Measure	Time frame
C-reactive protein ;Homocysteine;Daily Activity Assessment Scale(modified Barthel index,MBI);Fugl-Meyer Assessment;mini-mental state examination(MMSE);	—

Countries

CHINA

Contacts

Public ContactJiming Tao

Shuguang Hospital affiliated to Shanghai University of TCM

taoyecheng@163.com+86 133 8619 2862

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026