Mild Cognitive Impairment/Alzheimer's disease
Conditions
Interventions
Sham group:Sham rTMS+Sham tDCS
rTMS group:rTMS+Sham tDCS
tDCS group:Sham rTMS+ tDCS
rTMS+tDCS group:rTMS+tDCS
Sponsors
The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Volunteers who are aged 60 years or older and sign the informed consent form. 2. Subjects or informants report progressive and evolving changes in memory function for =3 months. 3. Presence of mild cognitive impairment or mild to moderate dementia 4. Sufficient reading, writing, and audio-visual abilities to undergo neuropsychological testing. 5. If using cognitive-enhancing drugs (such as donepezil, memantine), must have been on a stable dose for at least 3 months with no dosage adjustments during the enrollment period.
Exclusion criteria
Exclusion criteria: 1. History of neurological diseases such as brain tumors, head trauma, stroke, epilepsy, Parkinson's disease, or mental disorders. 2. History of metabolic diseases including anemia, thyroid dysfunction, folate, vitamin B12 deficiency, and other conditions that can lead to cognitive decline. 3. History of alcohol abuse or drug use within the past 2 years before screening. 4. Post-craniotomy/cranial defect. 5. Presence of metal or electronic implants (e.g., pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.). 6. Other serious illnesses that may affect the study. 7. Participation in other clinical studies concurrently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment-Basic;Auditory Verbal Learning Test-Huashan; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Dementia Rating;Pittsburgh sleep quality index;Geriatric Depression Scale;Digit span test;Trail Making Test A and B;Digit Symbol Substitution Test;Verbal Fluency Test;Alzheimer's disease assessment scale-cognitive section;Clock Drawing Test;resting-state cerebral functional magnetic resonance imaging;Near infrared imaging spectrometer;electroencephalogram; | — |
Countries
China
Contacts
Public ContactXiquan Hu
Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Outcome results
None listed