Skip to content

Different doses of intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during cesarean section: a trial for ED50 determination using an up-down sequential allocation method

Different doses of intrathecal dexmedetomidine as an adjuvant to plain ropivacaine for spinal anesthesia during cesarean section: a trial for ED50 determination using an up-down sequential allocation method

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085189
Enrollment
Unknown
Registered
2024-06-03
Start date
2024-06-10
Completion date
Unknown
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cesarean section under spinal anesthesia

Interventions

group 1:Each patient received a dose of 3ug of dexamethasone, and the first patient received a dose of 10mg of ropivacaine. Effectively defined as achieving bilateral T6 or above sensory blockade leve
group 2:Each patient received a dose of 6ug of dexamethasone, while the first patient received a dose of 8mg of ropivacaine. Effectively defined as achieving bilateral T6 or above sensory blockade lev

Sponsors

Guangzhou Women and Children's Medical Center Liuzhou Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.ASA Physical Status II;2.aged 18 to 45 years;3.term gestation (=37 weeks);4.singleton pregnancy;5.scheduled for elective cesarean section under combined spinal-epidural anesthesia (CSEA).

Exclusion criteria

Exclusion criteria: 1.contraindications to neuraxial anesthesia;2.BMI=40  kg·m-2;3.severe pregnancy complications (e.g., hemorrhage, preeclampsia, heart failure, severe anemia and diabetes mellitus with complications);4.use of sedative or analgesic drugs 2 h before surgery preoperative;5.heart rate (HR)<50 beats·min-1 with cardiac conduction or rhythm abnormalities;6.allergy to drugs used in the study;7. known fetal abnormalities.

Design outcomes

Primary

MeasureTime frame
The success or failure of the intrathecal block;

Secondary

MeasureTime frame
Sensory block leve;Motor block level;Visceral traction response;Muscle relaxation;Sedation score;Operative and postoperative side effects;Operative and postoperative pain scores;Time to first required supplemental analgesia after surgery;Satisfaction;Time to first urination after the extubation of the catheters;Time of first getting out of bed activity;

Countries

China

Contacts

Public ContactMo Xiaofei

Guangzhou Women and Children's Medical Center Liuzhou Hospital

13560336485@163.com+86 135 6033 6485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026