Patients undergoing painless gastrointestinal endoscopy under general anesthesia
Conditions
Interventions
Remimazolam group (sequential method):If a positive reaction occurs, the dose of remimazolam will be increased by 0.02mg/kg in the next patient, and in the event of a negative response, a 0.02mg/kg re
Propofol group (sequential method):If a positive reaction occurs, the dose of propofol will be increased by 0.2mg/kg in the next patient, and in the event of a negative response, a 0.2mg/kg reduction
Remimazolam group (experimental group):The ED95 dose of remimazolam was administered
Propofol group (control group):ED95 dose of propofol
Sponsors
Zhuji People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing painless gastrointestinal endoscopy under general anesthesia; 2. American anesthesiologist association (ASA) anesthesia grade I or II; 3. Aged 18-65 years; 4. body mass index (BMI) 18.5 - 29.9kg/m2.
Exclusion criteria
Exclusion criteria: 1. Severe hypertension or diabetes; 2. Coronary heart disease; 3. Central nervous system diseases; 4. Pathological obesity/obstructive sleep apnea; 5. Allergies to the study drug; 6. Take benzodiazepines intermittently or for a long time within 2 months before admission; 7. Schizophrenia and severe depression; 8. Acute upper respiratory tract infection or asthma attack; 9. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 95% effective doses of remimazolam and propofol;Changes in vital signs during the operation in the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| The success rate of sedation and adverse reactions in the two groups;Patient satisfaction and operator satisfaction; | — |
Countries
China
Contacts
Public ContactZhangjun Yan
Zhuji People's Hospital
Outcome results
None listed