depression
Conditions
Interventions
Treatment Group:antidepressant treatment
Sponsors
Hangzhou Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with Major Depressive Disorder (MDD) are as follows: 1) Age between 12 and 18 years, with no gender restrictions; 2) Diagnosed by two clinically experienced psychiatrists with the title of Deputy Chief Physician or above, through a consensus examination, based on the DSM-5 criteria for Major Depressive Disorder; 3) A score greater than 17 on the Hamilton Depression Rating Scale (HAMD-17) or a score of 40 or above on the Children's Depression Rating Scale - Revised (CDRS-R); 4) Subjects have not received antidepressant treatment in the past or have not been on antidepressant medication for at least two months prior to the study; 5) Both the subject and their family agree to participate in this study and have signed a written informed consent form. 3.1.2 Diagnostic criteria for MDD patients with anxiety and painful features: According to DSM-5, if a patient with depression exhibits at least two of the following symptoms for most of the time, they are defined as having anxiety and painful features: ? Feeling agitated or nervous; ? Feeling unusually restless; ? Difficulty concentrating due to worry; ? Fear that something terrible might happen; ? Feeling as if they might lose control of themselves. Additionally, the factor score for anxiety/somatization on the HAMD-17 should be 7 or higher. 3.1.3 Inclusion criteria for healthy control (HC) subjects are as follows: 1) Age between 12 and 18 years, with no gender restrictions; 2) No history of depressive disorder or other psychiatric disorders according to DSM-5, neither in the past nor currently, and their first-degree relatives also have no history of related psychiatric disorders.
Exclusion criteria
Exclusion criteria: 1. History of severe somatic diseases, neurological disorders, and cranial trauma. 2. Patients with mental retardation according to DSM-5, substance dependence or abuse (excluding nicotine and caffeine), obsessive-compulsive disorder, post-traumatic stress disorder, eating disorders, etc. 3. Individuals with implanted cardiac pacemakers, artificial heart valves, and other metallic implants in the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nocturnal ECG signal;Hamilton Rating Scale for Depression, HAMD-17;The Children’s Depression Rating Scale-Revised, CDRS-R; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Rating Scale for Anxiety, HAMA;Generalized Anxiety Disorder-7, GAD-7;Pittsburgh sleep quality index, PSQI; | — |
Countries
China
Contacts
Public ContactHaisi Chen
Hangzhou Seventh People's Hospital
Outcome results
None listed