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Effects of propofol combined with hypobaric bupivacaine and isobaric bupivacaine spinal anesthesia on early postoperative quality of recovery in elderly patients with lower limb fractures

Effects of propofol combined with hypobaric bupivacaine and isobaric bupivacaine spinal anesthesia on early postoperative quality of recovery in elderly patients with lower limb fractures

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085147
Enrollment
Unknown
Registered
2024-05-31
Start date
2024-06-03
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower extremity fractures in elderly patients

Interventions

A :Propofol 2mg/kg/h pump + bupivacaine L2-3 or L3-4 spinal anesthesia injection 2ml (bupivacaine 1.2ml (5ml, 37.5mg), sterilized injection water 1.8ml)
B:2ml of bupivacaine L2-3 or L3-4 for spinal anesthesia (bupivacaine 1.2ml (5ml, 37.5mg), sterilized injection water 1.8ml)
C:Propofol 2mg/kg/h pump plus bupivacaine L2-3 or L3-4 spinal anesthesia injection 1.6ml (5ml, 37.5mg)
D:Bupivacaine L2-3 or L3-4 for spinal anesthesia 1.6ml (5ml, 37.5mg)

Sponsors

Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Informed consent of patients and their families. 2. Patients had good treatment compliance and complete clinical examination data. 4. Elderly patients over 60 years old (systolic blood pressure no more than 180mmHg, diastolic blood pressure no more than 110mmHg). 5. All of them were closed fractures of the lower extremity, and the injury lasted for more than 24 hours. (including femoral fracture, tibiofibular fracture, hip fracture replacement)

Exclusion criteria

Exclusion criteria: 1. A history of allergy to local anesthetics and protein. 2. Severe respiratory diseases significantly affect the intraoperative oxygen saturation of patients. 3.ASA grade greater than grade III. 4. Heart disease, severe sinus bradycardia or severe atrioventricular block. The contraindications of intraspinal anesthesia: 1. Infection and deformity in the puncture site; 2. Infections of the central nervous system, such as meningitis and encephalitis

Design outcomes

Primary

MeasureTime frame
Quality of postoperative recovery;

Secondary

MeasureTime frame
Blood pressure;Heart rate;Postoperative shivering;

Countries

China

Contacts

Public ContactWangfangjun

Affiliated Hospital of North Sichuan Medical College

wfjlxy006@nsmc.edu.cn+86 134 5825 3172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026