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The efficacy and safety of bevacizumab combined with chemotherapy/TKI/immunotherapy for advanced non-small cell lung cancer: a real-world study protocol

The efficacy and safety of bevacizumab combined with chemotherapy/TKI/immunotherapy for advanced non-small cell lung cancer: a real-world study protocol

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400085138
Enrollment
Unknown
Registered
2024-05-31
Start date
2024-06-01
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non squamous non-small cell lung cancer

Interventions

Bevacizumab combined with chemotherapy group (A chemotherapy regimen that includes all chemotherapy drugs):None
Bevacizumab combined with TKI group (TKI drugs (including but not limited to ositinib, erlotinib, gefitinib, extinib, ametinib, aletinib, dacetinib, fumetinib, afatinib)):None
Bevacizumab combined with immunotherapy group (Immunotherapy drugs (including but not limited to Xindilizumab, Karelizumab, Pabolizumab, Nafenumab, Treprizumab, Tirelizumab, Sepalizumab, Pa'anprizumab

Sponsors

Jiangsu Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Visit on January 1, 2023 to December 31, 2023; 2) Age = 18 years old; 3) Locally advanced, recurrent, or metastatic non-small cell lung cancer confirmed by histology or cytology as inoperable; Indications for the use of bevacizumab according to clinical diagnosis and treatment conventions; 4) ECOG score 0-1 points; 5) Accept a treatment regimen containing bevacizumab combined with chemotherapy/TKI/immunotherapy.

Exclusion criteria

Exclusion criteria: 1) Merge patients with other malignant tumors; 2) Individuals who are allergic to bevacizumab and its excipients; 3) Individuals with severe damage to the liver, kidneys, hematopoiesis, and cardiovascular system; 4) Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
Progression free survival;Objective relief rate;

Secondary

MeasureTime frame
Incidence of adverse reactions;Type and severity of adverse reactions;

Countries

China

Contacts

Public ContactShaorong YU

Jiangsu Cancer Hospital

yushaorong2009@163.com+86 136 7518 4006

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026