Non small cell lung cancer
Conditions
Interventions
experimental group:Stereotactic Radiotherapy
Sponsors
Sir Runrun Shaw Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: age=18 2: Non small cell lung cancer patients who have experienced pulmonary metastasis after PD-1 immunotherapy in the past 3: Voluntarily participate in this study and sign an informed consent form 4: The presence of evaluable size and number of pulmonary metastases on chest CT 5: There are indications for lung puncture biopsy 6: General physical condition (ECOG) 0-1 7: The laboratory test meets the following standards: white blood cell count>3.5 × 109/L, absolute value of neutrophils>1.8 × 109/L, platelet count = 75 × 109/L, hemoglobin = 100g/L; NR = 1.5, and APTT = 1.5 times the upper limit of normal value or partial prothrombin time (PT) = 1.5 times the upper limit of normal value; Total bilirubin = 1.25 times the upper limit of normal value; ALT and AST50mL/min or blood creatinine<1.5 times the upper limit of normal value
Exclusion criteria
Exclusion criteria: 1: Unable to tolerate or refuse further immunotherapy 2: Vulnerable groups, including individuals with mental illness, cognitive impairment, critically ill patients, minors, pregnant women, illiteracy, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minor Residual Lesions;progression-free survival;overall survival;RTOG acute radiation injury grading;Quality of life scores;Lymphocyte subpopulation analysis; | — |
Countries
China
Contacts
Public ContactXiaonan Sun
Sir Runrun Shaw Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed