Alcohol Use Disorder
Conditions
Interventions
? oscillating TIs targeting DLPFC group:Targeted stimulation of DLPFC brain regions by ? oscillating TIs
? oscillating TIs targeting IPL group:Targeted stimulation of IPL brain regions by ? oscillating TIs
TIs pseudo-stimulation group:Given by the special pseudo-stimulation module of the TIs system, the stimulation program is the same, and the pseudo-stimulation group only sets 5 seconds of current in a
and blank control group:No intervention
Sponsors
Beijing Huilongguan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the clinical diagnostic criteria for moderate or severe alcohol use disorders of the fifth edition of the American Diagnostic and Statistical Manual of Mental Disorders (four or more items that meet the clinical diagnostic criteria); (2) Age 18-65 years old; (3) Acute withdrawal treatment has been completed, there are no obvious withdrawal symptoms, and the score of the Clinical Institution Alcohol Withdrawal Assessment Form is <7 points; (4) Voluntarily participate and sign informed consent; (5) Breath alcohol concentration =0; (6) Right-handed; (7) color vision, vision, hearing is normal or in the normal range after correction; (8) years of education =6 years; (9) To be able to provide time retrospective information on alcohol consumption during the 2 weeks prior to withdrawal; (10) Heavy drinking at least 2 times per week (=5 standard drinks per day for men and =4 standard drinks per day for women) during the 4-week period prior to withdrawal;
Exclusion criteria
Exclusion criteria: (1) Other mental disorders that meet the diagnostic criteria of the 5th edition of the American Diagnostic and Statistical Manual of Mental Disorders, such as bipolar disorder, schizophrenia, and mental retardation; (2) Those who have had less than a week of disappearance of psychiatric symptoms related to alcohol consumption or have stopped taking antipsychotic drugs for less than a week as a result; (3) Individuals who have clearly experienced epileptic seizures or delirium tremors; (4) Currently receiving other alcohol cessation treatments, including systematic psychotherapy; (5) Other psychoactive substance dependent individuals with comorbidities (excluding tobacco); (6) Individuals with any severe/uncontrollable systemic diseases (such as respiratory, circulatory, digestive, neurological, hematological, urogenital, endocrine system diseases); (7) Simultaneously taking other related alcohol cessation drugs, such as naltrexone or acaran acid; (8) Pregnant or lactating women; (9) Received physical regulation therapy such as transcranial alternating current, repeated transcranial magnetic stimulation, and non convulsive electroconvulsive therapy within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delayed matching to sample;MATRICS Consensus Cognitive Battery;Alcohol use disorder identification test;Eeg data;Barratt Impulsiveness Scale 11th;Self-rating anxiety scale,SAS;Self-rating depression scale,SDS;VAS assessment of alcohol craving; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of heavy drinking days;The proportion of days without alcohol consumption;The longest consecutive days without alcohol consumption;Average daily and weekly alcohol consumption;Rating of consequences for drinkers; | — |
Countries
China
Contacts
Public ContactKebing Yang
Beijing Huilongguan Hospital
Outcome results
None listed