Senile diseases
Conditions
Interventions
Control Group (intervention study):No exercise training
Moderate-intensity exercise group (intervention study):2 weeks, warm-up phase (10 min,100 W, 70 rpm) + HIIT (4min or 8min Wmax averaged exercise to 95% VO2max + 3min intervals, 5 cycles), 2x 5*8min HI
High-intensity exercise group (Intervention study):2 weeks, warm-up phase (10 min,100 W, 70 rpm) + HIIT (4min or 8min Wmax averaged exercise to 95% VO2max + 3min intervals, 5 cycles), 2x 5*8min HIIT +
Normal Exercise Group (Observational Study One):None
Overtraining group:None
None exercise group:None
Moderate intensity exercise group:None
High intensity exercise group:None
Sponsors
Xiangtan First People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Qualifying criteria for observational studies Inclusion criteria: 1.18.5 BMI<=23.9 kg/m^2; 2. Age should be between 18 and 55 years old, with no gender restrictions. 3. Good physical and mental health; 4. I or my close relatives can fully understand the informed consent form, agree to participate in the research and sign the informed consent form. Qualifying criteria for interventional research Inclusion criteria 1.18.5 BMI<=23.9 kg/m ²; 2. Age: no less than 18 years old and no more than 40 years old, gender not limited. 3. Good physical and mental health; 4. Those who have good compliance with the experiment and are qualified to participate in high-intensity exercise after physical examination; 5. I or my close relatives can fully understand the informed consent form, agree to participate in the research and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the observation group: Subjects will not be included in this observational study if they meet any of the following criteria: Those with chronic or active digestive tract diseases such as esophageal diseases, gastritis, gastric ulcers, enteritis, active gastrointestinal bleeding or those who have undergone digestive tract surgery; 2. Those with a history of any liver diseases, such as toxic hepatitis, drug-induced hepatitis, alcoholic liver disease, liver cirrhosis, primary liver cancer, liver tumors, or hereditary liver diseases; 3. Those with a history of cardiovascular system, endocrine system, urinary system, nervous system, respiratory system, hematology, immunology (including personal or family history of hereditary immune deficiency), psychiatry, metabolic disorders, etc., and whom researchers believe still have clinical significance at present; 4. Whether any medication has been used in the past 30 days; 5. Alcoholics or regular drinkers within the six months prior to the test, that is, those who consumed more than 14 units of alcohol per week (1 unit =360 mL of beer or 45 mL of 40% alcohol or 150 mL of wine); 6. Those with other bad living habits such as smoking. Exclusion criteria for the intervention group Subjects cannot be enrolled in this intervention study if they meet any of the following criteria: (1) Those who have participated in any drug clinical trial within three months prior to the trial; (2) Those who have had chronic or active digestive tract diseases such as esophageal diseases, gastritis, gastric ulcers, enteritis, active gastrointestinal bleeding or undergone digestive tract surgery within the past three years; (3) Those with a history of cardiovascular system, endocrine system, urinary system, nervous system, respiratory system, hematology, immunology (including personal or family history of hereditary immune deficiency), psychiatry, metabolic disorders, etc., and whom researchers believe still have clinical significance at present; (4) Those with a history of allergies to drugs, foods or other substances; (5) Those with a history of tumors, epilepsy, frequent headaches, or tuberculosis bacillus infection; (6) Those who cannot tolerate intravenous puncture or have a history of fainting at the sight of blood or needles; (7) Has undergone surgical operation within 3 months prior to the trial; Or those who plan to undergo surgical operations during the research period; (8) Those who have received the vaccine within three months before the trial; (9) Those who have used any drugs within 30 days prior to the test; (10) Blood donors or those who have lost a large amount of blood (> 400 mL) within 3 months prior to the test; (11) Alcoholics or regular drinkers within the six months prior to the test, that is, those who consumed more than 14 units of alcohol per week (1 unit =360 mL of beer or 45 mL of 40% alcohol or 150 mL of wine); Or those who are unwilling to stop drinking alcohol or using any alcoholic products during the trial period; Or the result of the alcohol breath test is positive (> 0.0 mg/100 mL); (12) Those who consume excessive amounts of tea, coffee and/or caffeinated beverages (more than 8 cups, 1 cup =250 mL) daily, or those who do not agree to stop drinking tea, coffee and/or caffeinated beverages during the trial period; (13) Those who have special dietary requirements, cannot follow a uniform diet, or are lactose intolerant; (14) Drug abusers or those who have used soft dr
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ?-glutamyl transpeptadase;Alanine amiotransferase;Aspartate aminotransferase;Total bile acid;Total bilirubin;Cholinesterase;Total protein;Albumin;Total cholesterol;Triglyceride;High density lipoprotein cholesterol;Low density lipoprotein cholesterol;Fasting and random blood glucose;HbA1c;Insulin;Abdominal ultrasonography;Carotid color ultrasonography;Heart color ultrasound;Abdominal CT scan;Brain magnetic resonance imaging;Body composition analysis;Bone mineral density;Stroop colour word test;Reaction Time Tests;Structural magnetic resonance imaging;Magnetic resonance spectroscopy, MRS;Transient elastography;Serum markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Body weight;Waist hip circumference;Blood pressure;Blood routine examination;Routine urine test;Stool tests;Chest CT;Skin test;Muscle test; | — |
Countries
China
Contacts
Public ContactGenqing Xie
The first people's hospital of Xiangtan hospital
Outcome results
None listed