Pathological scars
Conditions
Interventions
Experimental group 1:Injection of botulinum toxin type A 1U/0.1ml
Experimental group 2:Injection of botulinum toxin type A 2.5U/0.1ml
Experimental group 3:Injection of botulinum toxin type A 5U/0.1ml
Control group:Inject 0.9% physiological saline
Sponsors
Dezhou Hospital, Qilu Hospital, Shandong University
Eligibility
Sex/Gender
All
Age
12 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with emergency trauma; 2. Patients with skin swellings; 3. Patients with clear consciousness; 4. No mental retardation or cognitive difficulties; 5. Agree to participate in this study; 6. 12<= age <= 65 years old.
Exclusion criteria
Exclusion criteria: 1. Allergic to botulinum toxin type A; 2. Pregnant, lactating women, patients who plan to get pregnant in the near future; 3. Patients taking retinoic acid, synthetic steroids, amino glycosides antibiotics, calcium channel blockers, cyclosporine and cholinesterase inhibitors; 4. Neuromuscular diseases: such as myasthenia gravis, Lambert-Eaton syndrome, multiple sclerosis; 5. Patients with cardiovascular diseases, kidney diseases, liver and other basic diseases; 6. Patients with infection at the injection site; 7. Expect unrealistic patients.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction;Scar itching;Scar pain; | — |
Primary
| Measure | Time frame |
|---|---|
| Scar width;Scar height;Visibility of incision line ;Scar pigment change; | — |
Countries
China
Contacts
Public ContactLv Tao
Dezhou Hospital, Qilu Hospital, Shandong University
Outcome results
None listed