obstructive sleep apnea-hypopnea syndrome
Conditions
Interventions
obese group:Biased coin design method:The initial dose was 0.2 mg/kg with fixed increments of 0.05 mg/kg between dose levels.
nonobese group:Biased coin design method:The initial dose was 0.2 mg/kg with fixed increments of 0.05 mg/kg between dose levels.
Sponsors
Shanghai Children’s Hospital ,Shanghai Children’s Hospital,School of Medicine,Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: (1) ASA class I-II (2) Age 3-17 years (3) Body mass index (BMI) greater than the 95th percentile (obese group) or between the 25th and 84th percentile (control group) for age and sex, respectively;
Exclusion criteria
Exclusion criteria: (1) Preoperative use of anticonvulsants, tranquilizers, or medications for attention deficit disorder; (2) Confirmed diagnosis of heart, kidney, or liver disease; (3) Chronic hypertension; (4) Hypoalbuminemia; (5) Allergy to any of the study medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is remimazolam RSS = 4 three minutes after the 1-minute bolus is completed.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure (systolic, diastolic, mean) at baseline, 3min, 6min, 9min, 12min and 15min of infusion;Heart rate at baseline, 3min, 6min, 9min, 12min and 15min of infusion;SPO2 at baseline, 3min, 6min, 9min, 12min and 15min of infusion;respiratory rate at baseline, 3min, 6min, 9min, 12min and 15min of infusion;BIS at baseline, 3min, 6min, 9min, 12min and 15min of infusion;Adverse effects: including hypoxaemia, hypersensitivity, bradycardia, etc.; | — |
Countries
China
Contacts
Public ContactJiang Yan
Department of Anesthesiology, Shanghai Children’s Hospital ,Shanghai Children’s Hospital,School of Medicine,Shanghai Jiao Tong University
Outcome results
None listed